Early 20th century. Frank (Dwayne Johnson) is the charismatic captain of a peculiar boat that travels through the Amazon jungle. There, despite the dangers that the Amazon River has in store for them, Frank will take the scientist Lily Houghton (Emily Blunt) and his brother McGregor Houghton (Jack Whitehall) on his boat. Your mission will be to find a mystical tree that could have healing powers. Of course, their objective will not be easy, and in their adventure they will encounter all kinds of difficulties, in addition to a German expedition that also seeks this tree with healing properties. This action-adventure comedy is based on the Jungle Cruise attraction in Disney’s amusement parks.