In 2018, in Detroit, Damien, an expert in martial arts and crime infiltration, receives a new dangerous mission: to infiltrate the Brick Mansions, a city ghetto, and find a neutron bomb that has been stolen by Tremaine Alexander, the head of a gang of criminals. Helped by Lino, the gang member of Tremaine, a young man who knows the ghetto at perfection, Damien has to approach the most dangerous criminals in a hostile environment and deal with Alexander. The perfect opportunity for Lino to adjust her accounts with the bandit who kidnapped her fiancé.