1850. In full gold fever, Charlie (Joaquin Phoenix) and Eli Sisters (John C. Reilly) live in a wild world. The two brothers are gunmen and both have their hands stained with blood. Although he would give everything for his little brother, Eli (Reilly) dreams of being able to lead a normal life. A commission from El Comodoro (Rutger Hauer), which wants to eliminate a gold-seeking chemist, will take them from Oregon to California on an initiatory journey that will test the bond between the two brothers.
This film is directed by the French filmmaker Jacques Audiard (Dheepan, From oxide and bone), who co-writes the script with Thomas Bidegain (My daughter, my sister), from the book written by Patrick DeWitt. The film is starring John C. Reilly (The fat and skinny), Joaquin Phoenix (Mary Magdalene), Jake Gyllenhaal (Velvet Buzzsaw), Riz Ahmed (Venom), Carol Kane (Ghost Light) and Rutger Hauer (Valerian and the city of the thousand planets).