Barry Seal is a pilot for Trans World Airlines. When the CIA discovers that it traffics with cigarettes, it gives it an extremely important mission, a secret operation. Barry accepts the government proposal and embarks on South America. Soon, Pablo Escobar and his gang in the Medellin neighborhood find out about the exceptional talents of this American pilot and decides to recruit him to deliver cocaine to the US. Seal agrees to work for these traffickers who pay him very well. However, once in this situation, there is no escape.